Īmerican Congress of Rehabilitation Medicine (ACRM) Mild Traumatic Brain Injury Committee of the Head Injury Interdisciplinary Special Interest Group. Evaluation of white matter injury patterns underlying neuropsychiatric symptoms after mild traumatic brain injury. Mild traumatic brain injury: pathophysiology, natural history, and clinical management. Magnetic Resonance in Medicine, 45(5), 770–780Īlexander, A. Analysis of partial volume effects in diffusion-tensor MRI. A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: an ENIGMA rs-fMRI protocol. M., Jahanshad, N., Shukla, D., Turner, J., Grotegerd, D., Dannlowski, U., et al. Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol. Advanced diffusion MRI fiber tracking in neurosurgical and neurodegenerative disorders and neuroanatomical studies: A review. C., Pathak, S., Suski, V., Lacomis, D., Friedlander, R. We conclude that DWI is able to detect structural mTBI-related abnormalities that may persist over time, although future DWI research will benefit from larger samples, improved data analysis methods, standardized reporting, and increasing transparency.Ībhinav, K., Yeh, F. Longitudinal studies, though limited, generally indicate at least a partial normalization of DWI metrics over time, which is often associated with functional improvement. In the chronic phase of recovery, FA may remain low, possibly indicating overall demyelination or Wallerian degeneration over time. In contrast, acute/subacute adult studies most commonly indicate lower FA within the context of higher MD and RD. Many acute/subacute pediatric studies reported higher FA and lower ADC or MD in various regions.
Although heterogeneity of sample characteristics and study methods limited the consistency of findings, alterations in DWI metrics were most commonly reported in the corpus callosum, corona radiata, internal capsule, and long association pathways. Patterns of findings between studies were reported, along with strengths and weaknesses of the current state of the literature. Findings were reported independently for four subgroups: acute/subacute pediatric mTBI, acute/subacute adult mTBI, chronic adult mTBI, and sport-related concussion, and all DWI acquisition and analysis methods used were included. Articles were excluded if they were not full-length, did not contain original data, if they were case studies, pertained to military populations, had inadequate injury severity classification, or did not report post-injury interval. Findings were limited to human studies using DWI in mTBI. A PubMed literature search was performed using relevant indexing terms for articles published prior to May 14, 2020. This systematic review assesses patterns of differences in DWI metrics between those with and without a history of mTBI. There is evidence that diffusion-weighted imaging (DWI) is able to detect tissue alterations following mild traumatic brain injury (mTBI) that may not be observed on conventional neuroimaging however, findings are often inconsistent between studies.
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